NFL odds do not stop at the point spread and over under. There are numerous ways to bet on football these days, including the NFL money line, futures (odds to win the Super Bowl), along first half and second half betting lines. In NFL betting, the favorite must win by 12 points or. NFL betting lines and picks against the spread for every divisional . had yards passing last week, threw for yards and ran for a 2 -yard. NFL odds and spreads for the latest NFL games. NFL Odds: Week 1 .. Oddsmakers produce lines during the year, depending on the strength or weakness of.